Ruminations

Blog dedicated primarily to randomly selected news items; comments reflecting personal perceptions

Wednesday, March 08, 2023

Sleep 101: do NOT Stint on ZZZZZZZZs

"I think these findings emphasize that just getting enough hours of sleep isn't sufficient, you really have to have restful sleep and not have much trouble falling and staying asleep."
"It's never too late to exercise or stop smoking, it's also never too early."
"Even from a young age, if people can develop these good sleep habits of getting enough sleep, making sure they are sleeping without too many distractions and have good sleep hygiene overall, it can greatly benefit their overall long-term health."
“So, if we can improve sleep overall, and identifying sleep disorders is especially important, we may be able to prevent some of this premature mortality."
"And we should be talking about and assessing sleep more often."
Dr. Frank Qian, clinical fellow in medicine, Harvard Medical School
 
“Compared to individuals who had zero to one favorable sleep factors, those who had all five were 30% less likely to die for any reason, 21% less likely to die from cardiovascular disease, 19% less likely to die from cancer, and 40% less likely to die of causes other than heart disease or cancer.” 
Study Statement 

"That [gender differential in study outcomes] was an interesting part of the study for me, and I hope we can find that answer with more research. [One potential reason for that gender difference could be the difficulty of evaluating women for obstructive sleep apnea, a potentially deadly condition in which breathing stops every few minutes. The more severe the apnea, the greater the risk of coronary artery disease, heart attacks, heart failure and strokes]."
"Women with obstructive sleep apnea often get under-diagnosed or misdiagnosed because they may not present with the classic symptoms that we see when we’re evaluating men.Maybe we need to ask different questions or look at different parameters, or is there something we’re missing here?"
Dr. Raj Dasgupta, sleep specialist, associate professor of clinical medicine, University of Southern California’s Keck School of Medicine
Getting good sleep could add years to your life, a study suggests (Alamy/PA)
Getting good sleep could add years to your life, a study suggests (Alamy/PA)

A new study on the qualitative benefits of sleep was presented recently at the American College of Cardiology's Annual Scientific Session, Researchers involved in the study looked at data collected from 172,321 individuals participating in the National Health Interview Survey that took place between 2013 an 2018. 

It has been fairly well established by science that insufficient sleep will increase risk of health conditions such as high blood pressure, heart disease, obesity and diabetes. This study, however, shows for the first time that good sleep has benefits leading to increased life expectancy. To the present a premise that had never been put through a study microscope.

Now, scientists at Harvard University have definitively found that a good night's sleep has the potential to add years to one's life. Studying data from over 170,000 people, researchers found that those people who enjoyed good-quality sleep lived longer than those whose sleep patterns are found wanting in quality and duration.

According to the study, life may be extended by close to five years for men and over two years, for women. Eight percent of deaths from any cause may be linked to poor sleep, according to the study results. Those who realized the largest benefit slept for between seven and eight hours nightly and experienced no difficulty falling asleep, nor problems staying asleep.

And nor did any of these subjects make use of sleep medication. They routinely reported feeling well-rested on waking at least five days each week. Life expectancy in those who reported quality sleep was 4.7 years greater for men and 2.4 years for women.
"Certainly all of us... have those nights where we might be staying up late doing something or stressed out about the next day."
 "If that's a fairly limited number of days a week where that's happening, it seems like that's OK, but if it's occurring more frequently then that's where we run into problems."
Frank Qian, study co-author, Harvard Medical School 

Based on an assessment of five different factors in quality sleep, researchers determined the key habits for high-quality sleep are…

  1. Seven to eight hours of sleep per night
  2. Difficulty falling asleep no more than twice a week
  3. Trouble staying asleep no more than twice a week
  4. Not using any sleep medication
  5. Feeling well rested after waking up at least five days a week

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Thursday, December 30, 2021

Your Usual Dinnertime Tipple of Wine?

"Our study is now one more mosaic stone in the evidence which is coming to show that what we believed for decades might not be true."
"We undertook this research to ask, what kind of people are these [past habitual drinkers]? What characteristics do they have?
"If people talk about alcohol, they always warn of becoming alcohol dependent ... but these people are less than two percent of the health disorders which may accrue from alcohol. Prevalent health disorders -- cardiovascular disorders and cancers -- should be much more stressed, and particularly breast cancer. It's very, very important because it's the number one cancer among females."
"Alcohol has a very, very long tradition in culture. So, it will be a huge endeavour to go ahead with this message that the best is to stay abstinent from alcohol."
"We have all these lessons learned from the tobacco industry and the alcohol industry which acts in a very, very similar way. So they support studies and investigations about these hypotheses, and particularly resveratrol."
"The main message is that people should remember to reduce their drinking [regardless] of whether they are high consumers or very low consumers."
"[The best way to prevent alcohol-related health disorders] -- namely cardiovascular disease and cancers, and mortality as well -- [is not to drink it at all, which is in line with the World Cancer Research Fund's recommendations]."
Ulrich John, University Medicine Greifswald, Germany 
Wine.
The study contradicts most national guidelines which say there may be health benefits to one or two glasses of wine. Photograph: Inti St Clair/Getty Images
 
But ... but we've been assured for years -- decades -- that moderate consumption of alcohol is highly beneficial to human health -- haven't we? Now along comes research published in the journal PLOS Medicine that tells us otherwise. The study by Ulrich John of University Medicine and his colleagues in Greifswald, Germany carries an unequivocal message: if you consume alcohol and cite its health benefits, you might see merit at this point in reconsidering your devotion to alcohol as health-beneficial.

This Germany-based research team studied 4,028 adults, finding that increased mortality among abstainers may be explained in part by other factors; alcohol for example, or drug dependence, smoking and a general history of poor health. A glass of wine or a pint of beer daily to benefit health is being prescribed in many countries by doctors; belief in the benefits of modest amounts of alcohol is that widespread and pervasive. 

Older epidemiological studies inexorably led to this interpretation "with many shortcomings", suggesting that alcohol abstainers have a higher mortality rate than those who consume low to moderate amounts. No significant difference in mortality between abstainers in good health and those who drank moderately was found by the new study, countering recommendations to drink alcohol for good-health reasons.

Other health behaviours, suggested by accessible evidence, including sedentary lifestyle, tobacco and substance use, have a dose-dependent relationship with mortality and health disorders; in that the greater the exposure, the higher the risk that follows. In light of which Dr.John found it "very implausible" that alcohol should be singled out as an exception, with health benefits.

Dr. John's research group investigated 4,028 adults between 1996 and 1997 with the use of standardized diagnostic interviews, including "very exact" information on health, alcohol and drug use along with smoking habits. The researchers revisited their data two decades later, which included mortality information, and drew comparisons between alcohol abstainers and low to moderate drinkers to find that 91 percent of alcohol abstainers were former drinkers, and 72 percent identified with one at least risk factors, such as a former alcohol or drug use disorder; former risky alcohol consumption; efforts to cut down or stop drinking; daily tobacco smoking; or fair to poor health.

They found no statistically significant difference in mortality rate between the health abstainers without any "factors that predict early death" and those who consumed low to moderate amounts of alcohol. The Women's Health Initiative Observational Study showed drinking even small amounts of alcohol increases the risk of breast cancer, the most common type of cancer worldwide, the second-leading cause of death from cancer among women in many countries.

Alcohol consumption has the potential to raise blood pressure levels and it has been linked to increased risk of hypertension, itself a major cause of premature death. Unfortunately, there is no strong global movement to alert populations to the dangerous effects of alcohol, a hugely socially accepted relaxant. Risks associated with articles praising "immune-boasting cocktails" aside, as well as those promoting the antioxidant properties of red wine, alcohol benefits from its undeserved health-halo effect.

Resveratrol, an anti-oxident, is found in over 70 plant species, in particular grapes and it is often cited as vital to the purported health benefits of wine. "It is not known whether there is a safe and effective dosage for chronic disease prevention", the conclusion reached by the Linus Pauling Institute. However, most supplements contain 250 to 500 milligrams of resveratrol, while a 150-millilitre (five-ounce) glass of red wine contains less than a milligram (0.2 - 0.5 milligrams). "You have to take huge amounts to have an effect", cautioned Dr.John. "And based on the evidence we have right now these hypotheses do not make sense."

So the conclusion that Dr.John's study reaches, along with an increasing body of evidence, is that no matter how much you drink, drink less. Those who take note, might alter drinking habits, limiting it to a glass of wine on holidays and abstaining for all other ordinary, daily events. "Many people do not know that they are, in essence, alcohol dependent. And this is the best way to learn (by abstaining for defined periods of time)."

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